Ch13DNAOct14

Ch13DNAOct14 - MOLECULAR BLUEPRINTS Naming the Unknown...

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1 10-Oct-09 Gardiner 1 MOLECULAR BLUEPRINTS 3 B I O L O G Y 12 2 3 10-Oct-09 Gardiner 2 Naming the Unknown Substance • 1868 • Swiss biologist • Friederich Miescher • Analyzing pus 10-Oct-09 Gardiner 3 Naming the Unknown Substance Pus is inflammation exudate Bacteria, disintegrating tissue and white blood cells Naming the Unknown Substance • Extracted substance from white blood cells • Two components • One was protein • The other contained phosphorus, carbon, hydrogen and nitrogen • He named it nucleic acid • By 1895 it was realized chromosomes were made of this mixture Isolating DNA You can do this! 10-Oct-09 Gardiner 6 The Transforming Principle • Fred Griffiths – 1928 • Studied Streptococcus pneumoniae , a bacterium that causes pneumonia in mammals. • One strain, the R strain, was harmless. • The other strain, the S strain, was pathogenic.
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2 The Transforming Principle Like Fig. 13.2 The Transforming Principle Like Fig. 14.2 The Transforming Principle Griffith called this phenomenon transformation , a change in genotype and phenotype due to the assimilation of a foreign substance (now known to be DNA) by a cell. B I O L O G Y 12 2 3 10-Oct-09 Gardiner 11 Confirming DNA Oswald Avery Colin MacLeod Maclyn McCarty The Genetic Material
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3 B I O L O G Y 12 2 3 10-Oct-09 Gardiner 13 The Genetic Material • Avery’s Purified Principle • 1.
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Ch13DNAOct14 - MOLECULAR BLUEPRINTS Naming the Unknown...

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