exam_2009-spring-3-answers

exam_2009-spring-3-answers - Principles of Drug Action (BIO...

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Principles of Drug Action (BIO 365D) Test #3 Name:_____________________________ April 27, 2009 Each of the 12 multiple choice questions is worth 0.75 marks out of 30 . 1. Which of the following statements regarding teratogenicity is FALSE ? A. Alkylating agents (such as cyclophosphamide) that are used to treat cancer are also teratogenic. B. Teratogens can act in a highly specific manner, with some having effects on some points in development while others exert their effects at different times . C. Lipophilic teratogens are expected to exert their teratogenic effects for only a brief period following exposure. D. Animal studies can fail to detect teratogenicity due to differences in inter-species sensitivity to teratogens. E. Hydrophilic teratogens are expected to exert their teratogenic effects for only a brief period following exposure. 2. The time period LEAST sensitive to teratogens is A. Fetal period B. Embryonic period. C. The time between fertilization and implantation of blastocyst. D. The time during development doesn’t matter - all times exhibit equal degrees of susceptibility. E. The postnatal period. 3. Which one of these behavioural tests is NOT a test of an instinctive behaviour? A. A locomotion test B. A hot plate test C. A test that measures sexual behavior D. A fixed ratio test E. A test assessing aggression 4. Which of the following drugs impairs formation of new memories, leading to amnesia? A. Amphetamine B. Strychnine C. Vasopressin D. Cycloheximide E. ACTH 5. Which one of the following projections between brain regions is strongly implicated in mediating the reinforcing effects of drugs of abuse? A. Amygdala projecting to nucleus accumbens B. Frontal cortex projecting to amygdala C. Ventral tegmental area projecting to amygdala D. Nucleus accumbens projecting to ventral tegmental area E. Ventral tegmental area projecting to nucleus accumbens 6. Which of the following drugs produces its pharmacological effects promoting dopamine release? A. Ecstasy B. Methamphetamine C. Cocaine D. LSD E. Marijuana
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7. Which one of the following statements is FALSE ? A. A high percentage of Asians have a variant of alcohol dehydrogenase that metabolizes alcohol slowly and that is why they show flushing responses after alcohol consumption. B. Low initial sensitivity to ethanol increases the risk for the future development of alcoholism. C. Sons of alcoholic fathers are more likely to themselves become alcoholics. D. Behavioral dependence is the central problem in drug addiction, while tolerance and physical dependence are secondary features. E. Animal breeding experiments have produced different lines of rodents that will voluntarily consume high or low amounts of drug, illustrating the role of genetics in drug use. 8.
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exam_2009-spring-3-answers - Principles of Drug Action (BIO...

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