final_exam_2008 - Name:_ Principles of Drug Action (BIO...

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Name:____________________________ Principles of Drug Action (BIO 365D) Final Exam December 12, 2008 Each of the 34 multiple choice questions is worth 0.5 marks (for a total of 17 out of 40) . 1. The drug Fluoxetine is marketed by a number of different pharmaceutical companies under the names Prozac, Fontex, Ladose or Sarafem. Which one of the following statements is TRUE ? A. Fluoxetine is a proprietary name and Prozac is a common name. B. Prozac is a proprietary name and Fluoxetine is a common name. C. Fluoxetine is a proprietary name and Prozac is a non-proprietary name. D. Fluoxetine is a non-proprietary name and Prozac is a proprietary name. E. Fluoxetine is a non-proprietary name and Prozac is a common name. 2. A nicotine patch is an example of which type of drug administration? A. Intrathecal. B. Percutaneous C. Subcutaneous D. Sublingual E. Intraperitoneal 3. Which one of the following statements is FALSE ? A. Gap junctions are composed of aquaporins B. Occluding zonulae form continuous tight junctions to prevent drug molecules from passing between cells. C. Facilitated diffusion always occurs down transmembrane concentration gradients. D. The dye Evans Blue can be used to estimate the volume of blood plasma water. E. Fenestrated capillaries are found in excretory and secretory organs. 4. Which statement concerning the liver or kidney is TRUE? A. The portal vein supplies the majority of blood flow to the liver. B. The hepatic artery is responsible for bringing blood to the liver after it has perfused the digestive system. C. In the kidney, most solute reabsorption occurs in the loop of Henle. D. Solute reabsorption only occurs passively. E. ADH (vasopressin) makes the urine more dilute. 5. Which one of the following statements is FALSE ? A. Only free drug can exert a pharmacological effect. B. Binding to plasma proteins slows the rate of a drug’s metabolism. C. A patient suffering from hypoalbuminemia could reasonably be expected to exhibit faster drug metabolism or excretion. D After intravenous injection, the injected drug travels as a bolus for 2-3 circulation times. E Phase I and phase II drug biotransformation reactions result in the metabolite having a higher membrane:buffer partition coefficient than the parent drug. 6. Assume that at time point zero (t = 0), the concentrations of drug “X” and drug “Y” are both 100 mg/L. One hour later (t = 1 hr) the concentrations of both drugs are 50 mg/L. Assuming drug “X” is being metabolized by zero-order kinetics and drug “Y” is being metabolized by first-order kinetics, which one of the following statements is TRUE ? A. At time t = 2 hours, the concentrations of both “X” and “Y” are 25 mg/L B. At time t = 2 hours the concentration of “X” is 0 mg/L and the concentration of “Y” is 25 mg/L C. At time t = 2 hours the concentration of “X” is 25 mg/L and the concentration of “Y” is 0 mg/L D. At time t = 2 hours, the concentrations of both “X” and “Y” are 0 mg/L
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This note was uploaded on 11/04/2009 for the course BIO 365D taught by Professor Mihic during the Spring '08 term at University of Texas at Austin.

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final_exam_2008 - Name:_ Principles of Drug Action (BIO...

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