Lecture-28 - Behavioural Pharmacology II Effects of drugs...

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Behavioural Pharmacology II Effects of drugs on behaviour controlled by schedules of reinforcement To determine the effects of a drug on behaviour one first obtains a pre-drug ( placebo ) baseline of an animal’s performance of a measurable task and then test for a change in that behaviour after the drug is administered.
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Effects of drugs on learning and memory Learning can be defined as a semi-permanent change in behaviour resulting from the occurrence of a previous event. Memory is the storage of learned information in a manner that permits its recall into consciousness at a later time. Memory occurs in three steps: (1) registration of information in a transitory short-term form; (2) consolidation into a longer-lasting form, and (3) retrieval when required. Pituitary peptides have been shown to play a role in learning and memory. Hypophysectomized animals lacking the hormone ACTH (actually even a fragment of ACTH) show deficits in learning a shock-avoidance response; ACTH administration to these animals normalizes their learning abilities. Vasopressin delays the extinction of a learned behaviour such as shock-avoidance response; it thus aids memory.
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Drug effects on neurotransmitter systems affect behaviour The functioning of many neurotransmitter systems in the brain can be altered to change behaviour. Examples:
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This note was uploaded on 11/04/2009 for the course BIO 365D taught by Professor Mihic during the Spring '08 term at University of Texas at Austin.

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Lecture-28 - Behavioural Pharmacology II Effects of drugs...

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