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final-review 1 - The half-life of a drug is 4 hours and its...

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The half-life of a drug is 4 hours and its volume of distribution in a patient is 45 L. (A) What infusion rate is required to maintain a concentration of 20 mg/L in this patient? (B) What is the clearance of this drug? (C) What loading dose would you have to give this patient to bring him to 20 mg/L? (D) If you stopped infusing drug into this patient and he had a drug concentration of 20 mg/L at that time, how much time would elapse until his body concentration was 3.5 mg/L?
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In accordance with the plateau principle, if the half-life of a drug is 4 hours, how many hours will it take to reach 75% of the steady state concentration. A dose of 200 mg of drug X was rapidly given intravenously to your patient (assume instantaneous distribution throughout this drug’s volume of distribution). Six hours later the concentration of drug X in his plasma was 10 mg/L. The drug has a half-life of four hours. What is the volume of distribution of drug X in your patient?
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