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final-review - Sample Problems Mr Smith has been drinking...

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Sample Problems Mr. Smith has been drinking and is believed to have caused an accident at midnight. He flees but is apprehended by the police at 1 A.M. and scores 700 mg/L ethanol on the breathalyzer. He is brought to the police station and at 3 A.M. is administered a blood alcohol test, on which he scores 100 mg/L. Because the police know you have taken BIO 365, they are in awe of your pharmacological skills and ask you the following questions: 1. What was Mr. Smith’s blood alcohol level when the accident occurred? 2. Mr. Smith claims that he entered his favourite bar “Clem’s Cowchip Cafe” at exactly 10:55, quickly drank 2 beers and left at exactly 11 P.M. Smith weighs 77 kg and he looks to be 70% water. Assuming he really did do all his drinking almost instantly (and it was absorbed instantly) and he finished at 11 P.M. how many beers did Smith really drink, assuming each drink contains 14 g of alcohol? 3. What’s the half-life of ethanol in Mr. Smith’s body?
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11 PM midnight 1 AM 2 AM 3 AM 100 200 300 400 500 600 700 800 900 1000 Time of day Mr. Smith’s measured and extrapolated blood alcohol concentrations (in mg/L) X X 1100 1200 1300
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1. You know that alcohol metabolism follows zero-order kinetics, until the alcohol concentration falls to a very low blood level . Therefore you can extrapolate back in time to determine Mr. Smith’s blood alcohol level at midnight when the accident occurred. The dotted green lines
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