NyholmLectures4

NyholmLectures4 - Chapter 8 Lecture Outline Transcription,...

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Chapter 8 Lecture Outline Transcription, Translation, and Bioinformatics
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Microbiology: An Evolving Science 2 Replication, Transcription, Translation Repetitive processes Build polymers of nucleotides or amino acids All have 3 major steps Initiation Bind polymerizing machine, first monomer to template DNA polymerase, RNA polymerase, ribosome Elongation Read template, add next monomer DNA, RNA, Protein Termination Release machine and completed product
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Microbiology: An Evolving Science 3 RNA Polymerase, Sigma Factor RNA Polymerase is a large molecular machine 4 proteins in one complex α , β , β ′ , ϖ Binds DNA, reads sequence Polymerizes RNA Where on DNA to bind? Sigma ( σ ) factor Smaller protein Guides RNA polymerase to target DNA sequence Promoter
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Microbiology: An Evolving Science 4 Sigma Factors RNA polymerase σ factor DNA Multiple sigma factors σ 70 Guides RNA polymerase to most genes σ 32 Active when cell is stressed by heat Heat-shock response 32
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NyholmLectures4 - Chapter 8 Lecture Outline Transcription,...

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