bio125_lecture9 - Signal Transduction Neurons can change...

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Signal Transduction Neurons can change their state (ie. which receptors, channels, neurotransmitters, etc they want to open, modulate or express) depending on what they perceive is going on in their environment. They receive signals from other neurons (neurotransmitters) and other cells (hormones, growth factors, and trophic factors). They have specialized machinery that can transduce these signals to changes in their physiological state.
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Different types of cell-cell communication • Synaptic signaling • Paracrine signaling- acts over a short range • Endocrine signaling- secretion of hormones into the blood stream • Autocrine signaling-cell talks to itself • Membrane protein signaling-two cells next to each other signal through membrane proteins
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Endocrine Signaling
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Paracrine Signaling
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Autocrine Signaling
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Signaling by Membrane Proteins
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Components of signaling • Signal
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Three classes of signaling molecules
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Components of signaling Signal Receptor- the way to sense a signal.
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Types of receptors Channel linked receptors: example the ACh receptor, signal is neurotransmitter, depolarization is signal, Na+ channel is target. Enzyme linked receptors usually signal through protein kinases or protein phosphatases. Protein modiFcation then alters intracellular enzyme activity. G-protein coupled receptors: signal through trimeric G- proteins. The proteins can alter the function of many proteins. Intracellular receptors- hormone receptors-signal binds directly to an intracellular protein which then activates transcription.
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Categories of Cellular Receptors
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Categories of Cellular Receptors
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Components of signaling Signal Receptor- the way to sense a signal. Target molecules that mediate the cellular response.
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This document was uploaded on 11/06/2009.

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bio125_lecture9 - Signal Transduction Neurons can change...

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