10-6-09 - molecules Enzyme-substrate complex 5 3 2 1 6 4...

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Enzymes Definition Definition How enzymes work? How enzymes work? Substrate interaction Substrate interaction
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Figure 8.14 Energy profile of an exergonic reaction Progress of the reaction Products Reactants G < O Transition state Free energy E A D C B A D D C C B B A A
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Figure 8.15 The effect of an enzyme on activation energy Progress of the reaction Products Reactants G is unaffected by enzyme Course of reaction without enzyme Free energy E A without enzyme E A with enzyme is lower Course of reaction with enzyme
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Fig. 8.17 The active site and catalytic cycle of an enzyme Substrates Enzyme Products are released. Products Substrates are converted to products. Active site can lower E A and speed up a reaction. Substrates held in active site by weak interactions, such as hydrogen bonds and ionic bonds. Substrates enter active site; enzyme changes shape such that its active site enfolds the substrates (induced fit). Active site is available for two new substrate
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Unformatted text preview: molecules. Enzyme-substrate complex 5 3 2 1 6 4 Enzymes (continued) • Factors affecting enzyme activity Factors affecting enzyme activity – (temperature, pH) (temperature, pH) • Control of enzyme function: Control of enzyme function: – Inhibition of enzymes Inhibition of enzymes Figure 8.19 Inhibition of enzyme activity (a) Normal binding (c) Noncompetitive inhibition (b) Competitive inhibition Noncompetitive inhibitor Active site Competitive inhibitor Substrate Enzyme Cellular Respiration • Reading Assignment Chapter 9, pp. 162 - 184 • ATP: a source of energy for the cell • Cellular Respiration defined Cellular Respiration • Redox Reactions: Transfer of electrons • NAD + / NADH Glucose Metabolism Overview of three major steps • Glycolysis • Krebs (Citric Acid) Cycle • Electron Transport Chain...
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This note was uploaded on 11/06/2009 for the course BIOL 152 taught by Professor Niedenthal during the Fall '09 term at Kansas.

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10-6-09 - molecules Enzyme-substrate complex 5 3 2 1 6 4...

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