lecture outline 10_29

lecture outline 10_29 - to bind a molecule of GTP in place...

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Cell Communication Reading assignment: Chapter 11, pages 206–227 Cell signaling; signal transduction Definition of signal transduction pathways: a sequence of events that whereby a chemical signal outside the cell produces a response inside the cell Signal transduction pathways for steroid hormones Cyclic AMP as a second messenger Calcium as an intracellular signal: release of intracellular calcium via stimulation of IP 3 receptors GLOSSARY Signal transduction: A mechanism linking a mechanical or chemical (pathway) stimulus to a cellular response. G protein: A GTP-binding protein that relays signals from a plasma-membrane signal receptor, known as a G- protein linked receptor, to other signal-transduction proteins inside the cell. When such a receptor is activated, it in turn activates the G protein, causing it
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Unformatted text preview: to bind a molecule of GTP in place of GDP. Hydrolysis of the bound GTP to GDP inactivates the G protein. Cyclic AMP: cyclic adenosine monophosphate, a ring-shaped molecule made from ATP that a common intracellular signaling molecule (second messenger) in eukaryotic cells, for example, in vertebrate endocrine cells. adenylyl cyclase: An enzyme that converts ATP to cyclic AMP in response to a chemical signal. IP 3 (inositol triphosphate): The second messenger, which functions as an intermediate between certain nonsteroid hormones and the third messenger, a rise in cytoplasmic Ca ++ concentration. DAG (diacyl glycerol): Serves as a second messenger in stimulating the activity of protein kinase C. Phosphodiesterase: An enzyme that deactivates cyclic AMP....
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lecture outline 10_29 - to bind a molecule of GTP in place...

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