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10-23-08 mol bio class notes

10-23-08 mol bio class notes - animals 3...

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10/23/08 Bio 344 Transcription Activators 1. Modular a. DNA binding Domain b. Activation domain 2. Bind to the upstream on regulatory sequences -enhancers---> Orientation and position-independent -silencers -insulators **35S-uses combinatorial regulation, expressed everywhere Regulation of Transcription factors or “Regulating the Regulators” A lot of post- translational regulation: Why? -Quicker response time -Avoid silencing by keeping the transcription factor gene on (?) Some of the mechanisms: 1. Coactivators or mediators 2. Phosphorylation-dephosphorlyation : can be + or – (imp. In both plants and
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Unformatted text preview: animals) 3. Ubiquitination (deubiquitination): covalent attachment of ubiquitin (small protein) to lysines can modulate activity or trigger destruction 4. Sumoylation: covalent attachment of SUMO (small ubiquitin-like modifier) peptide to lysines, factor is inactivated but not destroyed 5. Acetylation: histone acetyltransferases (HATs) acetylate lysines on histone and non-histone proteins, can be + or DAB-DAB-Pol-F complex FEH-h has helicase and kinase-e stimulates h as far as we know but cant have h w/o e-a stabilizes____...
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