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Unformatted text preview: 01) A researcher measures the EPSP amplitude of a single CA3-CA1 synapse. He then applies Botulinum Toxin (BOTOX) very locally at this one synapse. Following a tetanus stimulus where he stimulates this and many other synapses he removes BOTOX. After waiting for a longer time so the synapse can recover from the BOTOX effect he again measures the EPSP amplitude of this one synapse. He will find that the EPSP amplitude: A) Increased (LTP). B) Decreased (LTD). C) Nothing changed. 02) Which of these answers applies to CaMK2? A) Targets synapsin, is activated by calcium and autophosphorylates B) Phosphorylates calmodulin, binds to synapsin and is involved in LTP C) Is activated by calmodulin, is involved in LTP and targets synapsin D) Autophosphorylates, targets calmodulin and binds to calcium 03) Adding voltage-sensitive calcium channels to the postsynaptic cell in a CA3-CA1 synapse has an effect on LTP induction. A) True. B) False. 04) Calmodulin-dependent Protein Kinase 2 (CaMK2) is involved in removing AMPA receptors from the cell membrane in a synapse. A) True B) False 05) A neuron has nicotinic Acetylcholine receptors. All voltage-sensitive channels have been blocked, by adding TTX and TEA. By stimulating more and more synapses, is it possible to observe a membrane potential of +40 mV? A) Yes. B) No. 06) The learning effect in Aplysia was predicted by Hebb's postulate. A) True. B) False. A B C D rec in Questions 07-10. The records to the right were obtained from intracellular recordings made from a pacemaker fiber in the heart. The top record was obtained when the heart was bathed in normal Ringers solution. The investigator then performed a number of manipulations on the solutions bathing the heart. In one manipulation, cesium, which blocks the Ih current, was added to the bathing solution. In another manipulation, TTX was added to the Ringer solution (no cesium was present). In a third, a small amount of muscarine was added (no TTX or cesium was in the bathing solution). In the fourth manipulation, cadmium, a calcium channel blocker, was added to the bath (no TTX or cesium was in the bathing solution). Mark on your Scantron which of the four records shown above, A, B, C or D, would have been obtained from the manipulations described above 07) _______D______was the record obtained when cesium was added to the solution. 08) ______A_______was the record obtained when TTX was added to the solution. 09) _______B______was the record obtained when muscarine was added to the solution. 10) ______D_______ was the record obtained when cadmium was added to the solution. 11) A synapse has ligand-gated channels that have a reversal potential of -51 mV. The threshold for action potential is -50 mV, the resting membrane potential is -70 mV. Is this synapse: A) Inhibitory....
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- Spring '09