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Fly as Model System Lecture 2006

Fly as Model System Lecture 2006 - Genes Control...

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Genes Control ... Development DNA: Physiology Behavior Infectious Disease Inherited Disease Technology
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Drosophila melanogaster
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WHY FLIES… 1) Great Genetics 2) Short life span 3) Small Size 4) Small (sequenced!) Genome
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Great Genetics!!! Function Protein Biochemical Function Gene Phenotype
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Red-Eyed and White-Eyed Fruit Flies
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Eye Color Production in Drosophila
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yellow
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ebony
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vestigial
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eyeless
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Curly
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Drosophila’s Contributions to Genetic Research 1910 First mutation: white eyes (T. H. Morgan ) 1913 First genetic map showing genes arranged in a linear order (A. H. Sturtevant) 1916 Proof that genes are located on chromosomes (C. B. Bridges) 1927 X-rays cause mutations and chromosomal rearrangements (H. J. Muller ) 1934 First physical mapping of a mutation (T.S. Painter) 1975 First physical mapping of a gene (D. S. Hogness) 1980 First comprehensive analysis of mutants that affect animal development  (C. Nusslein-Volhard, E. Wieschaus, E. Lewis ) Nobel Prizes
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Drosophila Life Cycle
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