Molecular Genetics 3

Molecular Genetics 3 - Molecular Genetics III 10/28/08...

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Molecular Genetics III 10/28/08 Francke 3 1 10/25/08 HumBio2A: Molec. Genetics III 1. The Central Dogma of Molecular Biology 2. Transcription 3. Regulation of Transcription Molecular Genetics III DNA to RNA: Transcription Figure 12.2 The Central Dogma Complementary mRNA Protein DNA Information flows in one direction when genes are expressed The Central Dogma 10/25/08 HumBio2A: Molec. Genetics III • The sugar is ribose How does RNA, ribonucleic acid differ from DNA, deoxyribonucleic acid ? • Contains uracil (U) instead of thymine (T) Usually one strand
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Molecular Genetics III 10/28/08 Francke 3 2 10/25/08 HumBio2A: Molec. Genetics III DNA Deoxyribo Nucleic Acid RNA Ribo Nucleic Acid Gene271.Francke1.2008 Nucleus 10/25/08 HumBio2A: Molec. Genetics III The Central Dogma DNA RNA protein The Watson-Crick structure suggested a means to translate the genetic code (genotype) to protein (phenotype) Q P L M C D T Note the colinearity of the DNA sequence and the amino acid sequence
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Molecular Genetics III 10/28/08 Francke 3 3 10/25/08 HumBio2A: Molec. Genetics III Transcription occurs in three phases : Initiation Elongation Termination How Is the Information Content in DNA Transcribed to Produce RNA? 10/25/08 HumBio2A: Molec. Genetics III Initiation requires a promoter —a special sequence of DNA to which RNA polymerase binds The promoter tells RNA polymerase where to start, which direction to go in, and which strand of DNA to transcribe Part of each promoter is the initiation site Initiation Initiation
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Molecular Genetics III 10/28/08 Francke 3 4 Elongation : RNA polymerase unwinds DNA
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Molecular Genetics 3 - Molecular Genetics III 10/28/08...

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