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Unformatted text preview: shows heritable variation in survival and reproduction. HIV infections are heterogeneous-extremely variable b/c retrotranscription is error-prone process. May have mutant retrotranscriptase AZT resistance has a genetic basis- passed from parent virions to offspring survival and reproductionhost immune response, rate of replication, ability to invade 1/22 in the prescence of AZT, % resistant virions will increasewhy the reversal??? changed to context of evolution-select for forms with survival advantages. AZT resistance comes at a cost-they were less fit before AZT used. WhenAZT treatment is stopped, conditions change and proportion of diseased cells decreases. Evolution is shortsighted-it doesn't know where it is going. Context dependence. Origin of HIV-tree thinking. Immunodeficiency does not always affect an animal adversely. Can be asymptomatic. phylogentics...
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This note was uploaded on 11/11/2009 for the course BIOEE 2780 taught by Professor Geber during the Spring '07 term at Cornell University (Engineering School).
- Spring '07