Lecture 5 Bio 320 9.10.09

Lecture 5 Bio 320 9.10.09 - Lipid Rafts If you prenylate a...

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9/10/09 Bio 320 Two ways to lipidate a protein Prenylate Eeranglgeranol Farnesol Acetylate Myristate Palmiate Phospholipids are amphipathic “Two natures” has water loving and water hating ends Polar hydrophilic exterior Liposomes are used for gene therapy Can put stuff on the inside and have it pass through a cell membrane Example: DNA
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Unformatted text preview: Lipid Rafts If you prenylate a protein it goes to the membrane but not the raft If you acylate a protein it goes to the raft Glycolipids are generally thought as signaling platforms, etc? Prostaglandins Thromboxanes HETEs NSAIDS (anti-inflammatory drugs) Cortizone blocks the same pathway by making more protein...
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