10-21-08 class notes 349 - 10/21/08 349 Somites...

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10/21/08 349 Somites Formation/review AP identity D-V/medio-lateral differentiation Hindbrain-rhombomeres Components If we increase concentration of FGF on the right side: still get somite formation but smaller than what they would have been normally. FGF keeps the cells in the undifferentiated state, and as it passes through cells are able to respond to signals and become somites. When you inhibit FGF with SVS402 Might conclude you would get larger somites, which is in fact what you see. There is a physical movement of FGF from anterior to posterior that allows cells to move when they respond to somite differentiation signals. Cells will respond to signals long before the FGF that we put there, all cells in region that differentiate into somites have already been through a series of oscillations that start early on. If you take out a region of pre somatic mesoderm that is anterior to the node still and flip it you see that it has already been somewhat determined. The cells once they leave the node they start to degrade the mRNA for FGF. Getting lots
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10-21-08 class notes 349 - 10/21/08 349 Somites...

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