10-28-08 class notes 349 - Bio 349 10/28/08 C. elegans...

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Bio 349 10/28/08 C. elegans overview (review) -linages -screens -life cycle Early Development -Cleavage -AP polarity -DV polarity -cell-cell interactions -homologous genes Heterochronic genes -micro RNAs -RNAi Rapid development time Embryogenis completed in 24 hours It will go through molts so that first larva that hatches at out of the age will go through these molts to become adult Embryos are transparent so you can see whats happening as they are developing One of the features that allowed people early on to follow the fate of the worm One way was to identify the daughters and daughters of daughters etc. In adult every cell has its history/ its ancestory worked out for it L1 (the first larva that hatches out of the egg) does not have all the cells Looks like a worm, has symmetry Doesn’t have gonads or volva and will develop in subsequent molts L1 larva has 558 cells After it goes through these molts it will have 959 cells in the adult Actually not every cell that is produced during embryogenesis About 1100 cells produced but 139 will dye and undergo programmed cell death Cell Death Discovered in C. Elegans because they were working out these linages Posteror cells of daughter of certain cell at some point dies in every worm A specific cell was always undergoing cell death Found this out by isolating mutations where this cell didn’t die Could then actually contribute to living cell Were able to show several mutations and a pathway that caused the cell to undergo cell death Undergoing bio_____ reactions that is part of development In nervous system important part of refining conections Able to be worked out because every cell is defined and they could isolate mutations that affected that cell death
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Very organized If something causes a mutation in an egleg… egl Numbered by order of discovery… egl-1, egl-2 Because they were characterizing the division patterns of over 1000 cells had linage from anterior to posterior and could identify all the way back to daughter cells C. Elegans was the first multicellular organism to have its genome sequenced 18-2000
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This note was uploaded on 11/11/2009 for the course BIO Developmen taught by Professor Stevens during the Spring '09 term at University of Texas at Austin.

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10-28-08 class notes 349 - Bio 349 10/28/08 C. elegans...

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