B1510_module3_6_pyruvate_metabolism (2)

B1510_module3_6_pyruvate_metabolism (2) - Pyruvate pathways...

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Pyruvate pathways How is pyruvate metabolized? Through respiration Through fermentation • What changes occurred as free O 2 became available? How does metabolism differ in eukaryotes vs prokaryotes? How do the metabolic pathways connect?
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Cellular Energy Pathways from Pyruvate Glucose (C 6 H 12 O 6 ) 2 NAD + + 2 ADP Respiration Fermentation glycolysis 2 ATP 2 Pyruvate 2 NADH
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Changes in free energy during glycolysis
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Q: Glycolysis is found in all domains of life and is therefore believed to be ancient in origin. What about the citric acid cycle, the electron transport chain, and the F1 ATP synthase? a) They evolved after accumulation of atmospheric oxygen began b) They evolved before accumulation of atmospheric oxygen c) Individual enzymes were present before accumulation of atmospheric oxygen, but served other functions such as amino acid metabolism d) They evolved only in eukaryotes e) They evolved only in animals
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In respiring cells, pyruvate is oxidized to CO 2 + acetyl CoA Two molecules of pyruvate are oxidized to 2 acetyl CoA + 2CO 2 , generating 2 NADH per molecule of glucose. http:// www.micro.siu.edu/micr201/chapter8N.html
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Citric acid cycle generates ATP, NADH and FADH2 by oxidizing acetate to CO 2
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Citric acid cycle: hub of cellular metabolism http://en.wikipedia.org/wiki/File:Citricacidcycle_ball2.png
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Citric acid cycle releases (and captures) more free energy than does glycolysis
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B1510_module3_6_pyruvate_metabolism (2) - Pyruvate pathways...

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