NPB%20112%2009%20synaptic%20transmission%20slides

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Unformatted text preview: 1 Synaptic transmission Outline: 10/1/09 10/6/09 I. Overview II. Synaptic transmission and vesicular theory of neurotransmitter release (Ch. 5) A. requires Ca++ B. vesicular theory (quantal) C. mechanism of release D. recycling III. Neurotransmitters and postsynaptic receptors (Ch. 6) A. Acetylcholine B. glutamate and GABA C. ligand-gated (ionotropic) vs. metabotropic (G-protein-coupled) D. neuropeptides Synapse! Fig. 1.3 a 2 Fig. 5.1 Fig. 5.3 3 Ca++ free (replace with cadmium) TTX, TEA added Fig. 5.10 presynaptic Microinject Ca++ or buffer into presynaptic terminal Fig. 5.11 4 Fig. 5.6 Neurotransmitter is acetylcholine * Low Ca 2+ conditions * In multiples of 0.4 mV Fig. 5.7 5 Box 4A Patch-clamp Can record current flowing through single ion channel i ~2 pA, corresponds to depolarization of ~ 0.4 V = effect of opening of single postsynaptic ion channel Quantal end-plate potential = 0.4 mV = 1,000 x 0.4 V (1,000 ion channels) Normal end-plate potential= 40 mV = 100 x 0.4 mV = 100 quanta = 100,000 channels Fig. 5.3 Action potential invades synaptic terminal 6 Fig. 5.8 unstimulated stimulated Ca ++ channels vesicles Fig. 5.13 A 7 Fig. 5.14 b Classification of Voltage-Gated Calcium Channel 1 Subunits (Yaksh, J Pain 7 (Suppl 1) S13-S30, 2006) T Ca v 3.3 1I T Ca v 3.2 1H T Ca v 3.1 1G Ca v 3 Low-voltage activated channels R Ca v 2.3 1E N (pain) Ca v 2.2 1B P/Q...
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This note was uploaded on 11/14/2009 for the course NPB 33042 taught by Professor Carstens during the Spring '09 term at UC Davis.

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