Study Guide Chapter 25 - mechanism. 6. What is the basis...

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Nucleotide Biosynthesis (Chapter 25) Review Questions 1. Name four different bases, and corresponding nucleosides and nucleotides found in DNA and RNA. 2. Write the committed step in pyrimidine biosynthesis? What is the mechanism by which CTP regulates pyrimidine biosynthesis? 3. What is the committed step in purine biosynthesis. How is it regulated? 4. Write the steps involved in the conversion of IMP to AMP and GMP. 5. Write the reaction catalyzed by ribonucleotide reductase and explain the catalytic
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Unformatted text preview: mechanism. 6. What is the basis for using of fluorouracil and methotrexate as anti-cancer drugs?. Include the steps that are inhibited by the drugs and the mechanism of inhibition. (Be specific) 7. Write the reactions by which guanine/hypoxanthine and adenine are converted to the corresponding nucleotide by salvage reaction. 8. is an effective drug for the treatment of Gout but not Lesch-Nyhan syndrome. Explain the biochemical basis for this difference....
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This note was uploaded on 11/14/2009 for the course BIOLCHEM 415 taught by Professor Michaeluhler during the Winter '06 term at University of Michigan.

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