311cFall09Homework3 - structure 5 Why can an enzyme not directly make a non-spontaneous reaction spontaneous 6 If an enzyme has an acidic amino

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Intro Bio I (BIO 311C), Fall 2009, Dr. Bushart Homework #3 1. Glycine (only has a hydrogen as its R-group/side chain) is listed in the nonpolar grouping of amino acid side chains. Will a single glycine (not part of a protein) mix with water (polar solvent) or oil (nonpolar solvent)? Why? You may need to look up the structure of glycine. 2. Would you expect there to exist L- and D-forms of glycine? How about the other amino acids? Explain. 3. Although certain sequences of amino acids are more likely to be found in alpha helices than others, why in general can we have a large variety of primary structures that can take on this form? 4. Apply what you know about the active sites of enzymes to generally describe what two requirements polypeptides need to meet in order to take on quaternary
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Unformatted text preview: structure. 5. Why can an enzyme not directly make a non-spontaneous reaction spontaneous? 6. If an enzyme has an acidic amino acid in its active site, why would switching that amino acid to a basic one likely be very disruptive to its functionality? 7. Heating a piece of DNA can denature it, just as it does to a protein. In the case of DNA, the loss of secondary structure leads to the separation of the strands. Would a piece of DNA that is “AT-rich” separate at a lower or higher temperature than a piece of DNA that is “GC-rich?” Why? 8. Polymerization of nucleic acids utilizes nucleoside triphosphates. Why is this reaction spontaneous in spite of being a condensation reaction?...
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This note was uploaded on 11/16/2009 for the course BIO 50465 taught by Professor Wandelt during the Spring '09 term at University of Texas at Austin.

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