Intro Bio I (BIO 311C), Fall 2009, Dr. Bushart Homework #6 1. Defects in intermediate filaments lead to blistering disorders because the cells in the layers of skin are easily separated. What other components might have also result in blistering disorders if they were defective? Explain. 2. The major adhesive protein of desmosomes is cadherin. Why would it be likely that the cells from the same tissue are held together through desmosomes? 3. Fluorescence microscopy most often utilizes antibodies (with a fluorescent marker linked to it) in order to mark and examine structures formed by specific proteins in cells. However, we always need to be aware of effects that our manipulations may have on the structures we are examining. Why might the use of fluorescent antibodies against cadherin proteins not give us an accurate depiction of how desmosomes function in cells? 4. Plant cells are capable of responding to touch. One of the steps in the response pathway to touch is an increase in Ca 2+
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