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311cFall09Midterm3ReviewQuestions_key (1)

311cFall09Midterm3ReviewQuestions_key (1) - Intro Bio I(BIO...

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Intro Bio I (BIO 311c), Fall 2009, Dr. Bushart For Midterm #3 1. “Goblet cells” are named for their goblet-like shape, which relates to their function in directionally secreting mucus. Mucus is a peptide with large amounts of saccharides covalently linked to it. a. Other than the cytoskeleton (which is asked about in part c) and plasma membrane, what is one organelle or structure that would be important for the functioning of these goblet cells? Briefly explain what it is doing in this cell. Rough ER as the starting point for proteins being secreted, Golgi as the organelle which can add sugar modifications to proteins, ribosomes to synthesize the protein to begin with, transport vesicles to carry the protein from compartment to compartment of the endomembrane system. Other answers might be accepted with sufficient reasons. b. Why would an NLS be unnecessary for this protein? This protein needs to enter the ER to be processed in the endomembrane system. An NLS would send the protein to the nucleus, which is not where it needs to be.
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