chap5 lec - LEHNINGER PRINCIPLES OF BIOCHEMISTRY Fifth...

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Unformatted text preview: LEHNINGER PRINCIPLES OF BIOCHEMISTRY Fifth Edition David L. Nelson and Michael M. Cox 2008 W. H. Freeman and Company CHAPTER 5 Protein Function Function of myoglobin (Mb) : oxygen-binding protein of muscle cells, functions in the storage and transport of oxygen for oxidation of cell nutrients. Function of hemoglobin (Hb) : binds oxygen in lung and transport and release oxygen in peripheral tissues such as muscle; also transport CO 2 from peripheral tissues to lung. Hb in arterial blood passing from lung to peripheral tissue is 96% saturated with O 2 ; in venous blood returning to heart Hb is 64% saturated with O 2. Thus , blood passing a tissue releases 1/3 of O 2 it (Hb) carries. Allosteric effect : the binding of a ligand with one site of the protein affects the bing of ligands at one or more other sites of the protein as a result of conformational changes. Upon binding O 2 on one subunit, Hb undergoes structural (conformational) changes, causing Hb switching from T to R. Since R has higher affinity for O 2 , the conformational changes cause cooperative ( + ) O 2-binding. HHb + O...
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This note was uploaded on 11/17/2009 for the course BIO CHM327 taught by Professor Liu during the Spring '09 term at Cal Poly Pomona.

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chap5 lec - LEHNINGER PRINCIPLES OF BIOCHEMISTRY Fifth...

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