Mid 2 Fall 2008

Mid 2 Fall 2008 - 1 of 2 BIS 102 Fall 2008 K Hilt Name Last...

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1 of 2 BIS 102 Name__________________________________________________ Fall, 2008 Last First K. Hilt Second Midterm Score (100): ___________ Equations: pH = pK a + log {[b]/[a]} Amino acid pK a ’s: -carboxyl group (2.1), -amino group (9.6) side chains: D (3.9) E (4.2) H (6.0) C (8.3) Y (10.1) K (10.5) R (12.5) Oligopeptide pK a ’s: C-terminal carboxyl group (3.6), N-terminal amino group (7.4) 1. Hemoglobin has both - and -subunits. Let’s focus on the -subunits for a moment. (25 pts.) a) Each -subunit has three different histidines whose R-groups participate, either directly or indirectly, in O 2 binding in Hb. One of the histidine R-groups forms a hydrogen bond, another forms a covalent bond, and the third forms an ionic bond. Identify each histidine with each bond type and then discuss how each is involved in O 2 binding or release by Hb. Which of these three histidines would you rank as the “most important” in O 2 communication in Hb? Why? (20 pts.) b) Identify all of the allosteric effectors that could bind to the
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Mid 2 Fall 2008 - 1 of 2 BIS 102 Fall 2008 K Hilt Name Last...

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