assign 5 biotransport

Assign 5 - Introduction to Biomechanical Engineering Assignment 5 Biotransport Due Area A Impermeable backing 1 A constant drug delivery rate can

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Assignment 5: Biotransport Introduction to Biomechanical Engineering Due: November 10, 2009 1. A constant drug delivery rate can be produced by having a drug in a reservoir at a high concentration and diffusing the drug across a membrane of thickness l (see figure). If the drug diffuses rapidly through the tissue and into the blood, the drug concentration in the tissue can be assumed to be zero. Determine the release rate (in g/s) of insulin from the reservoir into the tissue, if the diffusion coefficient of insulin is D = 1.5 x 10 -6 cm 2 /s. The insulin concentration in the reservoir is C r = 1.5 mM, the membrane thickness is 2 mm, the reservoir area is 25 cm 2 , and the molecular weight of insulin is 5808 g/mol. 2. A patient on a heart-lung bypass machine relies on efficient oxygen transfer into the blood. For adequate diffusion to occur, the Peclet number of the device must be less than 1000. If the patient has a cardiac output of 5 L/min, and the capillary tubes in the bypass machine are 1 cm in diameter, what is the minimum number of tubes required? Assume the diffusion coefficient of oxygen in blood is D O2 = 0.0000324

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This note was uploaded on 11/17/2009 for the course MEM 380 taught by Professor Lau during the Spring '07 term at Drexel.

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Assign 5 - Introduction to Biomechanical Engineering Assignment 5 Biotransport Due Area A Impermeable backing 1 A constant drug delivery rate can

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