short-path-evaporator-note - www.icheme.org/cherd doi:...

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COMPUTER-AIDED MODELLING OF SHORT-PATH EVAPORATION FOR CHEMICAL PRODUCT PURIFICATION, ANALYSIS AND DESIGN M. SALES-CRUZ and R. GANI ± CAPEC, Department of Chemical Engineering, Technical University of Denmark, Lyngby, Denmark A n important stage in the design process for many chemical products is its manufacture where, for a class of chemical products that may be thermally unstable (such as, drugs, insecticides, Favours / fragrances, and so on), the puri±cation step plays a major role. Short-path evaporation is a safe method, suitable for separation and puri±cation of thermally unstable materials whose design and analysis can be ef±ciently performed through reliable model-based techniques. This paper presents a generalized model for short-path evaporation and highlights its development, implementation and solution through a computer-aided modelling framework, which allows the use of systematic simulation strat- egies for various types of design / analysis problems. The main features of the model and the modelling framework are highlighted through two case studies: (a) the puri±cation of a reac- tion mixture containing glycerol, mono-, di- and triglycerides, and (b) the recovery of a pharmaceutical product from a six-component mixture. Validation of the short-path evapor- ation model is highlighted through the comparison of experimental data from an industrial pilot plant with the simulated results from the model. Also, results from model-based sensi- tivity analysis and design problem solution are highlighted for two case studies. Keywords: short-path evaporation; computer-aided modelling; product and process design; puriFcation INTRODUCTION Conventional distillation is one of the oldest methods to separate liquid or molten substances. However, it is not recommended for substances that can be degraded under distillation temperatures, such as vitamins, insecticides, drugs and Favours / fragrances. Short-path evaporation is a separation technique used as an alternative in various pro- cesses of the chemical, pharmaceutical, fragrance and food industry. It is a safe method suitable for separation and puri±cation of thermally unstable materials, through a small distance between the evaporator and the condenser, and characterized by low temperatures, short residence times of the distilled liquid on the thermally exposed sur- face and suf±ciently low pressure in the distillation gap (space between evaporator and condenser). This method is also called molecular distillation because the vapour path is unobstructed, and the condenser is separated from the evaporator by a distance less than the mean free path of the evaporating molecule. Therefore, the modelling, design and analysis of short-path evaporation (or molecular distillation) are important elements in many chemical product engineering problems.
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This note was uploaded on 11/20/2009 for the course CHME DTU-abroad taught by Professor Rafiqulgani during the Fall '09 term at Rensselaer Polytechnic Institute.

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short-path-evaporator-note - www.icheme.org/cherd doi:...

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