lect1Stat - Lecture 1 What/Why/How Statistics Sandrine...

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Unformatted text preview: Lecture 1: What/Why/How Statistics? Sandrine Dudoit Division of Biostatistics, UC Berkeley www.stat.berkeley.edu/~sandrine BE131/231 — Fall 2004 Introduction to Computational Molecular and Cell Biology c Copyright 2004, all rights reserved Sandrine Dudoit BIO ENG 131/231 — Fall 2004 Lecture 1 Compbio @ Berkeley Graduate Group in Computational and Genomic Biology cb.berkeley.edu • Designated Emphasis in Computational and Genomic Biology. • Courses. • Seminars. • Faculty profiles. • etc. October 11, 2004 Page 2 Sandrine Dudoit BIO ENG 131/231 — Fall 2004 Lecture 1 Outline • What/Why/How Statistics? • Introduction to R and Bioconductor Software. • Introduction to the Biology and Technology of DNA Microarray Experiments. • Numerical and Graphical Summaries of Data. • Basic Notions in Probability and Statistics. • Analysis of DNA Microarray Experiments: – Pre-processing: Image analysis and normalization. – Identification of differentially expressed genes: estimation and multiple hypothesis testing. – Prediction of biological and clinical outcomes based on microarray gene expression measures. October 11, 2004 Page 3 Sandrine Dudoit BIO ENG 131/231 — Fall 2004 Lecture 1 Lecture Notes www.stat.berkeley.edu/private/sandrine/BE131231.F04/ be131231.html October 11, 2004 Page 4 Sandrine Dudoit BIO ENG 131/231 — Fall 2004 Lecture 1 What is Statistics? Many views ... • We muddle through life making choices based on incomplete information . What makes Statistics unique is its ability to quantify uncertainty , to make it precise. This allows statisticians to make categorical statements, with complete assurance — about their level of uncertainty. (Gonick & Smith, 1993). October 11, 2004 Page 5 Sandrine Dudoit BIO ENG 131/231 — Fall 2004 Lecture 1 What is Statistics? Figure 1: Gonick & Smith (1993). Cartoon Guide to Statistics. October 11, 2004 Page 6 Sandrine Dudoit BIO ENG 131/231 — Fall 2004 Lecture 1 What is Statistics? Figure 2: Gonick & Smith (1993). Cartoon Guide to Statistics. October 11, 2004 Page 7 Sandrine Dudoit BIO ENG 131/231 — Fall 2004 Lecture 1 What is Statistics? Figure 3: Gonick & Smith (1993). Cartoon Guide to Statistics. October 11, 2004 Page 8 Sandrine Dudoit BIO ENG 131/231 — Fall 2004 Lecture 1 What is Statistics? • Statistics is the art of making numerical conjectures about puzzling questions . (Freedman et al., 1978). • The raw material of a statistical investigation is a set of observations ; these are the values taken on by random variables X whose distribution P θ is at least partly unknown . ... Statistical inference is concerned with methods of using this observational material to obtain information concerning the distribution of X or of the parameter θ with which it is labeled . (Lehmann, 1997)....
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This note was uploaded on 11/21/2009 for the course BIS bis 100 taught by Professor Dr.james during the Spring '09 term at UC Davis.

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lect1Stat - Lecture 1 What/Why/How Statistics Sandrine...

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