Chem 1A Research Project - RESEARCH QUESTION: How does...

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Unformatted text preview: RESEARCH QUESTION: How does laughing gas (nitrous oxide) inhibit pain? HYPOTHESIS: The chemical structure of laughing gas blocks pain receptors. NITROUS OXIDE AS AN ANESTHETIC: Nitrous oxide, or N O, was first discovered to be an anesthetic by a local dentist Dr. Horace Wells. During a nitrous oxide exhibit in 1844, a volunteer inhaled a significant dose of N O gas. Moments later the volunteer injured his leg walking back to his seat. Dr. Wells noticed this man had not noticed the injury until the gas had worn off. Dr. Wells hypothesized that N O may have been some form of a painkiller. The name laughing gas came to be when patients were seen laughing after an intake of N O gas. After many years of skepticism and experimentation, nitrous oxide became a common use of anesthesia in field of dentistry. 1 MOLECULES: OTHER ANESTHETICS: Ketamine ( C 13 H 16 Cl N O ) 2 Fig. 1 Dextromethorphan ( C 18 H 25 N O ) Fig. 2 Phencyclidine ( C 17 H 25 N ) Fig. 3 Nitrous Oxide (N O) Fig. 4 Fig. 5 Fig. 6 NMDA Receptor and NMDA (glutamate) 3 : Glutamate Fig. 7 NMDA receptor Fig. 8 CHEMICAL PRINCIPLES: Like the other anesthetics and glutamate, the structure of nitrous oxide is attracted to the structure of the NMDA receptor. Because glutamate is known to have both nitrogen and oxygen molecules that are attracted to the NMDA receptors, it has been discovered that the same forces are occurring when an N O enters the system (dipole-dipole attractions). 4 The N O acts as a channel blocker keeping the receptor from completing the task of increasing pain stimuli. DATA/RESULTS: NMDA RECEPTOR: When pain is detected during inflammation, the peripheral nociceptor C-fiber neurons...
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Chem 1A Research Project - RESEARCH QUESTION: How does...

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