Lect9_Slides - Viruses Part 2 – Gene Expression 1.  Why...

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Unformatted text preview: Viruses Part 2 – Gene Expression 1.  Why is gene expression controlled? 2.  Challenges faced for controlling gene expression by RNA viruses - prokaryotic vs. eukaryotic viruses 3.  Strategies used by RNA viruses -  -  -  -  -  Regulated translation Polyprotein cleavage Segmented genome Alternative splicing Transcription into monocistronic mRNAs Gene Expression During Infection Different genes expressed at different points in the infection cycle. Some proteins are needed at higher concentrations than others. Gene Expression During Infection – Eukayotic Cell Latent versus Infectious Early versus late proteins ssRNA(+) bacterial virus ssRNA(+) eukaryotic virus VPg = covalently attached viral protein Cleavage of a Polyprotein Segmented Genome ssRNA(-) eukaryotic virus Alternative Splicing ssRNA(+) virus transcription into monocistronic mRNAs ...
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This note was uploaded on 11/23/2009 for the course MIMG 101 taught by Professor Bradley during the Winter '08 term at UCLA.

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