9 Mutation - BIO 370 Kirkpatrick Hall Fall 2004 p 1 9 Mutation Mutation plays two roles in evolution It is the ultimate source of all new genetic

9 Mutation - BIO 370 Kirkpatrick Hall Fall 2004 p 1 9...

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BIO 370 Kirkpatrick & Hall, Fall 2004 p. 1 9. Mutation Mutation plays two roles in evolution It is the ultimate source of all new genetic variation It changes the frequencies of alleles that already exist in a population Most new mutations are deleterious (they decrease fitness) Data for typical new mutations in Drosophila When heterozygous, they reduce fitness by 3% When homozygous, they reduce fitness by 10% This is easy to understand: most random changes to an amino acid sequences will make an enzyme less efficient (Of course, some new mutations are advantageous) Any particular locus will reach a mutation-selection equilibrium Here the number of new mutations coming into the population is balanced by the number being removed by selection The frequency of the deleterious mutation is then:

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