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Unformatted text preview: Random mutations occur at every position in the viral genome One or two of these happen to interfere with AZT metabolism Those virus that carry these mutations survive AZT treatment Where did HIV come from? Analysis of genetic similarity between human HIV and similar primate viruses suggests it moved from chimpansees to humans in the 1930s Do human populations vary in resistance to HIV? The CCR5 resistance mutation seems to be hundreds of years old This allele may have spread during an earlier epidemic of another virus...
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- Spring '09