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Unformatted text preview: status? 3. The researchers determined the APOE sequences of several people with Alzheimers disease (AD) and without (controls). Table 4 shows the 10 common haplotypes they found. Which two haplotypes were least associated with AD? Which two haplotypes were most associated? Briefly, how was this determination made? 4. The first section in Table 5 shows the frequencies for each SNP minor allele among control individuals and those with D. (FYI, OR = odds ratio, see this link ). The data clearly show one SNP is strongly associated with AD. Which SNP is it and which allele of that SNP? 5. Four other SNPs show wekare but statistically significant associations with AD but the authors are skeptical about these associations. Why are they hesitant to interpret these associations and how do they rework the data to look more precisely for minor associations? 6. Read the discussion and tell me why the authors undertook this study and summarize their basic conclusions....
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This note was uploaded on 11/25/2009 for the course BI 379 taught by Professor Kavaler during the Spring '09 term at Colby.
- Spring '09