BI379_F09_Exercise_5_key

BI379_F09_Exercise_5_key - BI379 F09 Assignment 5 Due...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
BI379 F09 Assignment 5 Due Thursday, Oct 29 I. One of the classic examples of relating SNPs within a gene to a disease involves SNPs that define alleles of the apolipoprotein E (APOE) gene. Depending upon the alleles that one has, the likelihood of developing late-onset Alzheimer’s disease varies. A relatively recent paper in Human Molecular Genetics advances this work. Read the paper and answer the following questions. Belbin, O., et al., 2007. Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene and the rate of cognitive decline in Alzheimer's disease. Hum Mol Genet. 16, 2199-208. 1. List the three classical APOE alleles in order of their ability to confer INCREASING incidence of Alzheimer’s disease. ε 2 < ε 3 < ε 4 2. List all the APOE SNPs that are discussed in this paper. Give the RS number (when cataloged) as well as the nucleotide position relative to the transcription start site of the gene. Which of the SNPs are located in transcriptional regulatory regions? Which of the SNPs define the classical allele
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/25/2009 for the course BI 379 taught by Professor Kavaler during the Spring '09 term at Colby.

Page1 / 2

BI379_F09_Exercise_5_key - BI379 F09 Assignment 5 Due...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online