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BI379_F09_Exercise_6_key

# BI379_F09_Exercise_6_key - BI379 F09 Exercise 6 Key A How...

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BI379 F09 Exercise 6 Key A. How do you assess microarray data and cluster genes? 1. Read math minutes 6.1, 6.2, 6.3 2. Do Math Minute Discovery questions MM6.2 #1 and #2 MM6.3 # 1 – 4. MM6.2 #1: The diagonal entries of Table MM6.2 need not be calculated, because r AA = 1 for any gene A. Furthermore, the entries above (or below) the diagonal entries need not be calculated, because correleation is a symmetric function (i.e., r AB = r BA , for any two genes A and B). How many entries in Table MM6.2 must be calculated? 66. MM6.2 #2: Find a simple formula that represents the number of entries in Table MM6.2 that must be calculated (i.e., your answer to Q1) as a function of the number of genes being compared. number of entries = (x 2 – x)/2, where x = the number of genes being compared. MM6.3 #1: Compute the correlations between cluster [NH] and all other objects, forming a table similar to Table MM6.3. To do this, you need to average the expression values for N and H and then use them to calculate the new correlations between NH and the other objects.

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