Lecture29-2009-Li

Lecture29-2009-Li - 1 Fatty Acid Breakdown II Lecture 29...

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1 Fatty Acid Breakdown II Lecture 29 Chapter 20-2 and 3 Office hours: 1:00 to 2:00 pm CMM Room 142 Phone: 632-1401 Huilin.Li@StonyBrook.edu Next Wednesday morning - In class review evening – Exam 3 The breakdown in points is: Dr. Haltiwanger’s lectures 20-24 : 50 points Dr. Simon’s lectures 25-27 : 30 points Dr. Li’s: lectures 28-29 : 20 points
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2 Page 690 -oxidation of unsaturated fatty acids requires extra steps: wo cases: . Unsaturation at odd number. . Unsaturation at even number. (18:1 9) (18:2 9 12)
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3 Figure 20-15
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4 Figure 20-16 ß-oxidation of odd chain fatty acids: SCoA SCoA Proprionyl-CoA (not a substrate for AD) 15:0 6 rounds of ß-oxidation Biotin Vitamin B12 ?
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5 Methylmalonyl-CoA Cytosol Matrix Malate Pyruvate Malic Enzyme Figure 17-2
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Very long chain fatty acids (>22C) are oxidized in peroxisomes ß-oxidation same as in mitochondria, except first enzyme, Acyl-CoA oxidase: – Donates electrons to O 2, ( not FADH 2 ) , to form H
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Lecture29-2009-Li - 1 Fatty Acid Breakdown II Lecture 29...

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