Lecture31-2009-Li

Lecture31-2009-Li - 1 Cholesterol Biosynthesis Lecture 31...

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1 Cholesterol Biosynthesis Lecture 31 Chapter 20-7 Office hours today: 1:00-2:00pm [email protected]
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2 Cholesterol Functions Essential component of membranes: modulates fluidity and permeability . Precursor for bile salts : natural detergents in gut. Precursor for steroid hormones : e.g. estrogens, testosterone. Made from Acetyl-CoA More Nobel prizes (13!) given for understanding synthesis/metabolism than for any other molecule.
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3 Cholester ol is synthesized from Acetyl-CoA Figure 9-10a 27C (2C -> 1 Nobel prize) OH group at C3
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4 Cholesterol is the precursor to steroid hormones: Figure 9-11
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5 Cholesterol is the precursor to bile acids: Figure 20-1
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6 Cholesterol Biosynthesis Four stages: 1. Acetyl-CoA to HMG-CoA to isopentenyl- pyrophosphate (C5). 2. Condensation of 6 isopentyl- pyrophosphates to make squalene (30C). 3. Cyclization of squalene to make lanosterol. 4. Modifications of lanosterol to make cholesterol.
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7 Isopentenyl-pyrophosphate is an isoprene: Page 721
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8 HMG-CoA made from 3 molecules of Acetyl-CoA (cytosolic isozymes of those for Ketone Body synthesis): Figure 20-21
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9 Synthesis of isopentenyl- pyroposphate: Recall HMG-CoA made during Ketone Body synthesis in mt . Cytoplasmic isozymes for cholesterol biosynthesis. Figure 20-37
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Rate-limiting enzyme in cholesterol biosynthesis. Major regulatory site.
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This note was uploaded on 11/26/2009 for the course BIO 361 taught by Professor Lake during the Fall '08 term at SUNY Stony Brook.

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Lecture31-2009-Li - 1 Cholesterol Biosynthesis Lecture 31...

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