CHE327lecture8

CHE327lecture8 - Announcement Hand in Myristic Acid result...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Announcement Hand in Myristic Acid result form and sample Lidocaine Local Anesthetic N O N N N H Cl O O N CH 3 Local Anesthetics O O O CH 1880s CH 3 Cocaine O Alfred Einhorn 1905 H N O N H H 2 N Procaine (Novocaine) N O N Nils Löfgren 1943 Lydocaine Mode of Action ‐ Blocks the Sodium Channel N O N O N N H H H N O N N O N + H + pKa = 7.9 What percent of lidocaine is in the acid form in the blood (pH = 7.4) ? [H+][A [HA [H+][A-] [HA] = 10-7.9 or 10 .5 = [HA] [A-] A. 100% B. >99% C. ~75% D. ~25% E. <1% F. 0% N N H O N Lydocaine N H NO 2 Cl O Cl H N Cl NH 2 SnCl 2 H 2 O sodium acetate acetic acid O HCl, acetic acid Carboxylic Acid Derivatives O O H 2 N O H 2 O amide HO SOCl 2 thionyl chloride Cl acid chloride H 2 N N H carboxylic O HO acid O N H H O Cl H 2 N Base O ester Which reaction is the fastest? O O H 2 N N H O A Cl H 2 O HO B HO O O C The first step is to make the amide. O Cl O Cl sod um ace a e H N O Cl NH 2 sodium acetate acetic acid O Step 1. Weigh out sodium acetate and dissolve in water. Save for later Step 2. Dissolve 3 mL of the dimethylaniline in...
View Full Document

This note was uploaded on 11/26/2009 for the course CHE 327 taught by Professor Josephlauher during the Fall '08 term at SUNY Stony Brook.

Page1 / 4

CHE327lecture8 - Announcement Hand in Myristic Acid result...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online