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Unformatted text preview: Announcement Hand in Myristic Acid result form and sample Lidocaine Local Anesthetic N O N N N H Cl O O N CH 3 Local Anesthetics O O O CH 1880s CH 3 Cocaine O Alfred Einhorn 1905 H N O N H H 2 N Procaine (Novocaine) N O N Nils Löfgren 1943 Lydocaine Mode of Action ‐ Blocks the Sodium Channel N O N O N N H H H N O N N O N + H + pKa = 7.9 What percent of lidocaine is in the acid form in the blood (pH = 7.4) ? [H+][A [HA [H+][A-] [HA] = 10-7.9 or 10 .5 = [HA] [A-] A. 100% B. >99% C. ~75% D. ~25% E. <1% F. 0% N N H O N Lydocaine N H NO 2 Cl O Cl H N Cl NH 2 SnCl 2 H 2 O sodium acetate acetic acid O HCl, acetic acid Carboxylic Acid Derivatives O O H 2 N O H 2 O amide HO SOCl 2 thionyl chloride Cl acid chloride H 2 N N H carboxylic O HO acid O N H H O Cl H 2 N Base O ester Which reaction is the fastest? O O H 2 N N H O A Cl H 2 O HO B HO O O C The first step is to make the amide. O Cl O Cl sod um ace a e H N O Cl NH 2 sodium acetate acetic acid O Step 1. Weigh out sodium acetate and dissolve in water. Save for later Step 2. Dissolve 3 mL of the dimethylaniline in...
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This note was uploaded on 11/26/2009 for the course CHE 327 taught by Professor Josephlauher during the Fall '08 term at SUNY Stony Brook.
- Fall '08
- Organic chemistry