AssignedProblemSet6_2009

AssignedProblemSet6_2009 - Assigned Problem Set 6,...

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Assigned Problem Set 6, Fundamental Genetics 2009 Question 1 In the following pedigree, assume no outsiders marrying in carry a disease allele. a) What is the mode of inheritance of this disease? Circle one. autosomal dominant mitochondrial inheritance y-linked x-linked dominant autosomal recessive x-linked recessive b) Explain your choice in a). Give two lines of reasoning. c) Write the genotypes of the following individuals (if more than one genotype is possible, write down all the possibilities). #1 #2 #3 #4 #5
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d) Name a disease that follows this pattern of inheritance. (you may go to OMIM to answer this…. http://www.ncbi.nlm.nih.gov/omim ) Once you have found a disease that follows this pattern, briefly describe the disease as well as its clinical features and pathogenesis. e) What is the probability that the asterisked individual will be affected with the disease if male?____________ if female?___________ Question 2 Sorting through Nusslein-Volhard’s mutant lines, you discover a maternal effect mutation
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AssignedProblemSet6_2009 - Assigned Problem Set 6,...

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