AssignedProblemSet5_2009

AssignedProblemSet5_2009 - Assigned Problem Set 5 November...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Assigned Problem Set 5 November, 2009 1. You’ve learned about the Gal4/UAS system in flies; you will need to understand this system to answer the following question. Let’s say you are studying a gene ( herky jerky ) that when mutant causes epilepsy in flies. Even though this mutant is homozygous viable, it has some anatomical defects on its legs in addition to the epileptic behaviors. You would like to knock out the function of this gene ONLY in the brain and not anywhere else (obviously, the mutant is mutant everywhere in the body) in order to show that the epilepsy is due to defects specifically in the brain. Devise an experiment using the Gal4/UAS system to knock out herky jerky function in the brain. Hint: you don’t necessarily need a mutation in a gene to knock out its function. 2. A hypothetical mutant repressor, which functions as a dimer with two identical subunits, is tested for the ability to bind to mutant operators with the following results. Numbers in the table indicate relative tightness of binding . (a) What conclusions can you draw about inter-molecular contacts between the wild-type repressor and the wild-type
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/29/2009 for the course BIOLOGY 2:128 taught by Professor Leicht during the Fall '09 term at University of Iowa.

Page1 / 2

AssignedProblemSet5_2009 - Assigned Problem Set 5 November...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online