M2 Key 2.2002

M2 Key 2.2002 - _Key_ Last name Circle TA name _ First name...

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______Key_______ _________________ _________________ Last name First name Student number Circle TA name Paula Wade John Andy Stacey 2nd Midterm Exam LS 4 Lecture 2 Feb 11, 2002 BE SURE TO SHOW YOUR WORK FOR FULL CREDIT 1. Joey has sickle cell anemia. Applying protein electrophoresis to blood hemoglobin from Joey and his parents gave these results: There are many Joey’s in this world with identical electrophoretic results. What do they tell us about sickle cell anemia? Mutant changes in homoglobin cause sickle cell anemia. (The sickle cell mutation is in the gene encoding hemoglobin.) Joey’s sister was typed and has only the fast band. What is the chance she is a heterozygous carrier for sickle cell anemia? zero
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2. Pure breeding strain crosses of black x agouti mice give all agouti progeny. Black x cinamon give all cinamon colored progeny. A cross of the agouti F1 x the cinamon F1 from the above crosses give 50 agouti, 25 cinamon and 25 black progeny. How many genes for coat colors differ between the black, agouti and cinamon strains? 1 (all alleles of the same gene) Propose gene and allele designations to explain these results. Indicate the dominance relations between the alleles. Black = aa cinamon = a c a c Agouti = AA A/a x a c /a cross gives 2:1:1 ratios Dominance series: A is dominant to a c which is dominant to a (ie. A > a c > a). 3.
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M2 Key 2.2002 - _Key_ Last name Circle TA name _ First name...

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