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Endocrine Disease - Endocrine Diseases VS 441 Diabetes...

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Endocrine Diseases VS 441
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Diabetes mellitus Disorder of blood glucose regulation Main control of BG levels is by insulin Secreted by beta cells of pancreatic islet Insulin is essential in getting glucose into cells
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Diabetes Causes—largely unknown can be due to true insulin deficiency 2ndary to islet cell destruction impaired secretion Peripheral insulin resistance
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Diabetes Insulin deficiency results in gluconeogenesis by liver Glucose remains in circulation, cannot get into cells Result is hyperglycemia Ketones generated by liver from lipid breakdown when glucagon stores exhausted Accumulation of ketones overwhelms buffering ability, result is diabetic ketoacidosis
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Diabetes Clincal presentation PU/PD Weight loss polyphagia Exercise intolerance Visual deficits—dogs Cystitis--dogs Plantigrade stance--cats
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DM Laboratory Hyperglycemia Increased alk phos, ALT, cholesterol Glucosuria UA—consistent with UTI CBC—mild anemia, stress leukogram
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DM
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