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Liver diseases2 - Infectious,toxic,metabolic,degenerative...

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Liver diseases Liver subject to damage from many fronts— any significant alteration of normal body  physiology will  have effects  Infectious, toxic, metabolic, degenerative,  neoplastic  Primary or secondary Can be in three major categories: Diseases resulting in hepatocellular necrosis Diseases resulting in cholestasis Diseases resulting in liver atrophy or fibrosis   
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Inflammatory  Most commonly seen category—defined by  elevation in enzymes associated with  hepatocyte damage: ALT , AST primarily. Infectious— Infectious canine hepatitis—CAV-1 Rarely seen due to vaccination Causes marked hepatocellular necrosis “Blue eye” from corneal edema  Numerous bacteria, fungi, parasites can also infect  liver Hematogenous/lymphatic spread Biliary From neighboring organs
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Uncommonly, dirofilariasis can cause  acute liver necrosis and sudden death— vena cava syndrome Sudden weakness, marked   ALT, BSP,  bilirubinemia, hemoglobinuria, azotemia On necropsy, large numbers of adult worms in  pre and post cava, severe congestion of liver
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Non-infectious—majority of liver disease seen   in small animals
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