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PsychopharmLecture5_

PsychopharmLecture5_ - Lets go back up the ladder We have...

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Lets go back up the ladder We have gone from behavior, to molecular biology and now we are headed back toward behavior
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Drugs and synaptic transmission We already know that a drug can bind to a receptor, and either competes with the neurotransmitter for the binding site, or binds on an adjacent site on the protein (allosteric modulation). Now what are other ways that a drug can influence synaptic transmission?
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Traditional Synapse
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4 Types of Chemical Synapse --Wired Transmission-- 1. Axo-Somatic 1. Axo-Dendritic 1. Axo-Axonic 1. Dendro-dendridic
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Defining a Neurotransmitter 1. The substance must be present within the pre-synaptic neuron 1. The substance must be released in response to presynaptic depolarization, and the release must be Ca++ dependent 1. Specific receptors for the substance must be present on the post-synaptic cell. The putative neurotransmitter must elicit a response in the post-synaptic cell.
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Types of Neurotransmitters Classical Non Traditional Hormonal (Peptides)
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PsychopharmLecture5_ - Lets go back up the ladder We have...

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