PsychopharmLecture4_Ch3-1

PsychopharmLecture4_Ch3-1 - PrinciplesofChemicalTransmission

Info iconThis preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
Principles of Chemical Transmission 3 Dimensions of chemical transmission Space Time Function (pre and post-synaptic) Co-localization of neurotransmitters
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Chemical Transmission Space Wired Transimission – Classical chemical synapse Active zone, release into restricted area on a single  neuron “Volume Transmission” – neurotransmitter spills from site  with passive diffusion – Affects many neurons Time Fast (ionotropic) – Open ion channels Slow (metabotropic) – 2nd messenger pathways
Background image of page 2
Chemical Transmission Continued Function Excitation-secretion coupling:  Ca++  dependent process Vesicles near active sites of the axon terminal dock, fuse  and release the neurotransmitter Some neurotransmitters, like Monamines are packaged  “on site” in the axonal terminal Transporter, or reuptake pump, brings neurotransmitter  back into the cell from the synaptic cleft
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Chemical Transmission Continued Function (PreSynaptic) Precursors for Peptides are produced in cell body, transported  down the axon and where they enter synaptic vesicles and are  converted into peptides for release at the terminal. No (or limited) transport of peptides back into cell, instead  enzymes break down the peptides in the synaptic cleft.
Background image of page 4
1-9 Stahl S M, Essential Psychopharmacology (2000) pre-pro peptide gene endoplasmic reticulum primary mRNA prepropeptide mRNA prepropeptide signal peptidase propeptide converting enzyme synaptic vesicle peptide peptide catabolic peptidase inactive metabolite Some Examples of Peptides in the CNS: Substance P – Signals Pain Prodynorphin – Reduces pain Enkephalin – Reduces pain
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Peptides – Large Vesicles
Background image of page 6
Principle of Co-Localization
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Now Let’s Talk About Now Let’s Talk About Receptors Receptors 1. Organization of a single receptor 1. 3 Types of Receptor 1. Receptor Subtypes and Ligand Binding Agonists/Antagonists Allosteric Modulation
Background image of page 8
1. Organization of a Single 1. Organization of a Single Receptor Receptor 3 parts of a receptor Extracellular domain Transmembrane domains Intracellular domain A string of amino acids form the protein, and the amino acids wind their way in and out of the cell membrane, which gives rise to the extracellular, transmembrane and intracellular portions of the receptor Naming of Receptors – The amino acids that form the receptor give the name, ex. From book – tyrosine kinase (Trk) receptors are derived from the amino acid tyrosine .
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
outside of the cell
Background image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/01/2009 for the course PSYCH 50513 taught by Professor Cooper during the Spring '09 term at TCU.

Page1 / 47

PsychopharmLecture4_Ch3-1 - PrinciplesofChemicalTransmission

This preview shows document pages 1 - 11. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online