Intro.bio.StOlaf - Basic Concepts of Molecular Biology...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Basic Concepts of Molecular Biology *from a bioinfo. point of view. .. To be recalled to those trained in exact sciences: nothing is 100%true Contents: 1. Life 2. Proteins 3. Nucleic Acids 4. Molecular Genetics (mechanisms). 5. How the Genome is studied 6. Sequence Databases 1
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
1. Life Living organism: due to complex array of chemical reactions, exchanges constantly matter and energy with its surroundings, no deadlock. The main actors in the chemistry of life(biochemistry ) are molecules called proteins ("we are our proteins") and nucleic acids . Molecular biology research: basically devoted to the understanding of the structure and functions of proteins and nucleic acids. 2
Background image of page 2
2. Proteins Most substances in our bodies are proteins: -structural proteins act as tissue building blocks -enzymes: act as catalyst of chemical reactions A protein is a chain of amino acids. It has a central carbon to which is attached : - a H -an amino group NH 2 - a carboxy group COOH -a side chain particular to each amino acid 3
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4
Background image of page 4
5
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Protein (cont.1) In a protein, amino acids are joined y peptide bonds : the C belonging to COOH of protein A i bonds to the NH of protein A i+1 and a water molecule is liberated. What we really find inside a polypeptide chain is a residue of the original amino acid. Thus, we generally speak of proteins having 10 (typivally from 300 to 5000) residues. Repetition of blocks -N-C α -CO- is the backbone . The convention is that a polypeptide chain begins at the amino group (N-terminal) and ends at the carboxy group (C-terminal). 6
Background image of page 6
7
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Structures: The primary structure is the sequence of the residues. The secondary structure takes in account local interactions between atoms of the backbone (α_helix , β-sheet , loops ). The tertiary structure expresses the folding in 3D. Quaternary structure
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/01/2009 for the course BIO BIO130 taught by Professor Goralka during the Spring '09 term at Diablo Valley College.

Page1 / 28

Intro.bio.StOlaf - Basic Concepts of Molecular Biology...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online