Lecture6-7-Ch4-Sept17-19_2007

Lecture6-7-Ch4-Sept17-19_2007 - 5 views of a globular...

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The peptide bond...
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Resonance forms of the peptide bond:
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The Phi/Psi convention of protein backbone conformation
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A Ramachandran plot describes allowable conformation
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Alpha helix
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Beta sheets
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Beta turns
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Ramachandran plot for 1 protein: pyruvate kinase
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Structural propensities of amino acids
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Example of a fibrous protein : keratin
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Crosslinking & “perms”:
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red = Glycines Collagen triple helices  (not  alpha helices!)
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Collagen
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Silk fibroin
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Human serum albumin, 585 amino acids long The real dimensions (approximately)
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Unformatted text preview: 5 views of a globular protein (myoglobin) A few recurring motifs: Examples of protein “folds” Symmetry of protein complexes rotational symmetry axes Ribonuclease A refolds spontaneously Proteins do not fold by randomly testing conformations. Given a 100 amino acid protein Assuming 10 possible conformations per amino acid, how many possible conformations could the protein adopt? Action of Hsp70 ( = DnaK in E. coli bacterium) GroEL/ES...
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