PancreaticEndocrinology

PancreaticEndocrinology - Lectures On Pancreatic...

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Lectures On Pancreatic Endocrinology Joseph Dunbar Wayne State School Of Medicine
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A CELLS D CELLS B CELLS Glucagon Somatostatin Insulin
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Islet Insulin
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Islets Cell Types Of Pancreatic
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Islet boundary β-Cells (blue) secrete insulin in response to elevated plasma glucose levels α-Cells (red) secrete glucagon to maintain hepatic glucose production in fasting state 30 MM Pancreatic Islet α -Cells and β -Cells Play a Key Role in Glucose Regulation
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Structure of Human Proinsulin
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Chromosomal DNA (Nucleus) Cap site INT 1 INT 2 Poly A site 3’ 1500 bp Gene 5’ RNA (cytoplasm) 550 nt Polysome (Protein Synthesis) Pre- B C A SH SH HS C SH SH SH SH HS HS B Membrane of endoplasmic reticulum Completed proinsulin chain Endoplasmic Reticulum C “Folded” proinsulin Golgi Secretion Granule Converting enzymes C Peptide Insulin
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Glucose Amino Acids Ketones Acetyl Choline G.I. Hormone Glucagon Growth Hormone Cortisol Beta Cell Somatostatin Epinephrine Norepinephrine Insulin
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Secretion
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PancreaticEndocrinology - Lectures On Pancreatic...

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