Lecture_Adrenal Endo09

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Unformatted text preview: Lecture
–Adrenal
Endocrinology
 Glucocor4coid
 Metabolism
Of
Glucocor4coids
 •  Bound
to
Cor4coid
Binding
Globulin
(CBG),
 Transcor4n
50‐70%
 •  Bound
to
Albumin
20‐50%
 •  CBG
acts
as
a
buffer
 •  Half‐life‐
70‐90
min
 •  CBG
increased
by
estrogens
and
decreased
by
 starva4on
 •  Excreted
following
conjuga4on

 Characteris4cs
Of
Adrenal
Excess
 Characteris4cs
Of
Adrenal
Insufficiency
 Mineralocor4coid
 Aldosterone‐Site
of
ac4on
 •  •  •  •  Kidney
 G.I.
 Salivary
Glands
 Sweat
Glands
 Ac4ons
Of
Aldosterone
 Metabolism
of
Mineralocor4coids
 •  Binding
to
Plasma
proteins
is
low
 •  Half‐life‐15‐20
min
 •  Metabolized
by
the
liver
 Sex
Steroids
 Lecture
Adrenal
Medulla
 Ac4on
of
Epinephrine
 ...
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